Assistance Publique – Hopitaux de Paris (AP-HP) is a public Health establishment with 7 affiliated universities. There are now 39 hospitals within its ranks: 23 of which are acute, 20 adult and 3 pediatric. It is the largest university hospital in Europe with its sites located in the Paris region. AP-HP provides healthcare, teaching and research. AP-HP also trains foreign professionals.
The center of cognitive neurology (CCN) is managed by Prof Jacques Hugon and is a department of the University Lariboisière Hospital which belongs to Assistance Publique-Hôpitaux de Paris and which is affiliated with the University of Paris Diderot. It has been created in 2008 and includes the Memory Center validated by the Ministry of Health of the French government.
The building is located in the old Lariboisière Hospital and include rooms for our patient’s consultations, and beds for day care hospitalizations. About 3600 patients are seen in the CCN every year by neurologists, neuropsychologists, speech specialists and social workers. The mean age of the patients in around 64 years old and diagnostics include Alzheimer, DLB, Parkinson, LFTD, HIV cognitive troubles, etc,….
The CNC is well connected with many other University departments of Lariboisiere Hospital including vascular neurology, Internal medicine, neurosurgery, infectious disease MRI and PET imaging. The diagnosis is also carried out with lumbar punctures which are widely performed in day care beds. The CNC has 4 neurologists and 1 geriatrician, 7 neuropsychologists, and 2 speech specialists.
This is a center for clinical trials and pre-clinical research is done in an INSERM Unit managed also by Pr. Jacques Hugon.
Staff members
PI
Full Professor, MD (Neurologist), PhD in neurosciences, former research associate at the Albert Einstein College of Medicine in New York and Chair Professor at the Faculty of Medicine of Hong Kong / Queen Mary Hospital. Prof Hugon has been head of Cognitive Neurology Center since 2006, department of the Lariboisière Hospital (Assistance Publique-Hôpitaux de Paris). He is also co-leader of an INSERM Unit (U942) on Translational Research in neurodegenerative diseases. His research currently focuses on the molecular mechanisms of neurodegeneration, on CSF and blood biomarkers in Alzheimer’s disease, new therapeutic targets and he is involved in many clinical trials focusing on MCI, Alzheimer and other neurodegenerative diseases.
Prof. Hugon has 8 clinical trials running currently and is responsible for a an Academic Research INSERM Team “Biomarkers and neurocognition” (transgenic animals, neuronal cultures, experimental therapeutics).
Member
Junior associate professor, MD (Neurologist), PhD in neurobiology. Dr Cognat is involved in daily care and clinical research on patients with neuropsychiatric disorders and Behavioural and Psychological Symptoms of Dementia (BPSD). Member of a local work group on acute agitation. He will be co-investigator in an upcoming clinical trial in patients with BPSD and Alzheimer’s disease. He is also member of Cognitive Neurology Centrer, department of the Lariboisière Hospital (Assistance Publique-Hôpitaux de Paris). Prof Hugon INSERM team and has a special expertise in immunochemistry.
Member
Full Professor, MD (Neurologist), PhD in neurosciences, former research fellow at Southampton University. Prof Paquet is involved in daily care of patients with neurocognitive disorders. She has a peculiar experience in the management of patients with behavioural troubles including young familial Alzheimer‘s disease patients and fronto temporal dementia. She is PI in several academic clinical projects and in clinical trials for the Cognitive Neurology Centrer, department of the Lariboisière Hospital (Assistance Publique-Hôpitaux de Paris). She is a member of Prof Hugon’s INSERM Unit (U942) and is a renowned specialist of biomarkers of neurodegenerative disorders. She is also working as a team leader on the consequences of Abeta immunotherapies on the brain.
Member
Associate Professor, MD (Neurologist), PhD in epidemiology. Former Research associate at Havard Medical School. Dr Dumurgier is involved in daily care of patients with neurocognitive disorders, including patients with BPSD. He is co-PI of several clinical trials and international cohorts, including a clinical trial on Lewy body dementia for the Cognitive Neurology Centrer, department of the Lariboisière Hospital (Assistance Publique-Hôpitaux de Paris). He is also a researcher in neuroepidemiology and has a special interest in gait disorders in demented and MCI patients.
